Director: Vascular Biology Research Group
- 2001-date: Associate Professor, School of Biotechnology, Dublin City University.
- 1999-date: Adjunct Professor, Dept. of Surgery and Pharmacology, University of Rochester, Rochester NY, USA.
- 1999-2001: Senior Lecturer, School of Biotechnology, Dublin City University.
- 1999-1999: Professor, Dept. of Surgery and Pharmacology, University of Rochester, Rochester NY, USA.
- 1997-1999: Associate Professor, Dept. of Surgery and Physiology, Georgetown University, Washington DC, USA.
- 1995-1997: Assistant Professor, Dept. of Surgery and Physiology, Georgetown University, Washington DC, USA.
- 1992-1995: Research Associate, Dept. of Surgery, Johns Hopkins Medical Institution, Baltimore MD, USA.
- 1991-1992: Research Associate, Dept. of Physiology and Biophysics, University of Tennessee, Memphis TN, USA.
- 1990-1991: Postdoctoral Fellow, Dept. of Pharmacology, New York Medical College, Valhalla NY, USA.
- 1986-1990: Ph.D. in Receptor Pharmacology, Dept. of Pharmacology, University College Dublin.
- 1982-1986: B.Sc. in Pharmacology, Dept. of Pharmacology, University College Dublin.
Research Interests
- Tissue engineering: Bone and vascular tissue replacement technology
- Vascular remodeling: The role of hemodynamic forces (shear stress and pulse pressure) associated with the flow of blood on smooth muscle cell proliferation, migration, differentiation and apoptosis
- Endothelial control of vascular smooth muscle cell proliferation and migration: The role of mitogen activated protein kinase regulation of uPA and MMP gene expression
- The cardioprotective effects of alcohol on smooth muscle cell migration and proliferation
- The vasculopathy of portal hypertension: A role for mechanical force induced changes in endothelial nitric oxide synthase and cyclooxygenase gene expression
- Hepatocellular carcinoma (HCC): The role of a- and bg-subunits of inhibitory guanine nucleotide regulatory proteins (Gi-proteins) and their modulation of ras-mitogen activated protein kinase signaling in HCC tumors
Recent Publications
- Coyle, S., Sweeney, C., Hennessy, C., Walls, D. and Cahill, P.A. (2001). The role of notch signaling in aortic vascular smooth muscle cells. Supplement to Circulation 104: 89. [peer reviewed poster - American Heart Association, Anaheim, CA]
- Cummins, P.M., Coen, P.M. and Cahill, P.A. (2001). Regulation of endopeptidase EC 3.4.24.15 expression in vascular endothelial cells by mechanical forces. Supplement to Circulation 104: 298. [peer reviewed poster - American Heart Association, Anaheim, CA]
- Birney, Y., Redmond E.M., Sitzmann J.V.S. and Cahill, P.A. (2001). Prostaglandins in portal hypertension and cirrhosis. Prostaglandins and other Lipid Mediators, in press.
- Cahill, P.A., Redmond, E.M. and Sitzmann J.V. (2001). Endothelial dysfunction in portal hypertension and cirrhosis. Pharmacol Therapeutics 89: 273-293.
- Redmond, E.M., Cullen, J.P., Cahill, P.A., Sitzmann, J.V., Stefanson, S., Lawrence, D.A. and Okada, S. (2000). Endothelial cells inhibit flow-induced smooth muscle cell migration: role of plasminogen activator inhibitor-1. Circulation 30: 597-603.
- Redmond, E.M., Sitzmann, J.V. and Cahill, P.A. (2000). Potential mechanism for the cardiovascular protective effect of ethanol. Pharmacol Acta Sinica 21: 385-390.
- McKillop, I.H., Schmidt, C.M., Cahill, P.A. and Sitzmann, J.V. (1999). Guanine nucleotide regulatory protein induced activation of MAPK in hepatocellular carcinoma. Eur J Gastro Hep 11: 761-768.
- Schmidt, C.M., McKillop, I.H., Cahill, P.A. and Sitzmann, J.V. (1999). The role of cAMP-MAPK signaling in the regulation of human hepatocellular carcinoma growth in vitro. Eur J Gastro Hep 11: 1393-1399.
- Cappadona, C., Redmond, E.M., Theodarakis, N., McKillop, I., Hendrickson, R., Chhabra A., Sitzmann, J.V. and Cahill, P.A. (1999). Phenotype dictates the mitogenic response of vascular smooth muscle cells to changes in pulse pressure Exp Cell Res 250: 174-186.
- Hendrickson, R.J., Cappadona, C., Yankah, E., Sitzmann, J.V., Cahill, P.A. and Redmond, E.M. (1999). Sustained pulsatile flow regulates endothelial nitric oxide synthase and cyclooxygenase expression in co-cultured vascular endothelial and smooth muscle cells. J Mol Cell Cardiol 31: 619-629.
- Hendrickson, R.J., Cahill, P.A., Sitzmann, J.V. and Redmond, E.M. (1999). Ethanol enhances basal and flow-stimulated endothelial nitric oxide synthase activity in vitro by activating an inhibitory guanine nucleotide protein. J Pharm Exp Ther 289: 1293-1300.
- Hendrickson, R.J., Okada, S., Cahill, P.A., Yankah, E., Sitzmann, J.V. and Redmond, E.M. (1999). Ethanol inhibits basal and flow-induced vascular smooth muscle cell migration in vitro. J Surg Res 84: 64-70.
- Redmond, E.M., Cahill, P.A., Hirsch, M., Wang, Y.N., Sitzmann, J.V. and Okada, S. (1999). Effect of pulse pressure on vascular smooth muscle cell migration: the role of urokinase and matrix metalloproteinase. Thromb Haemost 81: 293-300.
- Kouretas, P.C., Kim, Y.D., Cahill, P.A., Myers, A.K. , Lam, N., Wang, Y., Sitzmann, J.V. and Hannan, R.L. (1999). Non-anti-coagulant Heparin prevents coronary endothelial dysfunction after brief ischemia reperfusion injury in the dog. Circulation 99: 1062-1068.
- McKillop, I.H., Vyas, N., Schmidt, C.M., Cahill, P.A. and Sitzmann, J.V. (1999). Enhanced Gi-protein mediated mitogenesis following chronic ethanol exposure in a rat hepatoma cell line. Hepatology 29: 412-420.
- McKillop, I.H., Schmidt, C.M., Cahill, P.A. and Sitzmann, J.V. (1999). Altered expression of Gq/G11- proteins in rat hepatocellular carcinoma; possible role in tumour growth. Hepatology 29: 371-378.
